The 1975 series, which starred Bonnie Franklin, Valerie Bertinelli and Mackenzie Phillips, concerned a newly divorced mother who relocated to Indianapolis with her teenage daughters.
The 13-episode Netflix remake is being penned by Gloria Calderon Kellett ("How I Met Your Mother") and Mike Royce ("Everybody Loves Raymond").
The comedy, Deadline reports, "revolves around a Cuban-American family, centering on a recently separated former military mom who is navigating a new single life while raising her radical teenaged daughter and socially adept tween son, with the 'help' of her old school Cuban-born mom and a friends-without-benefits building manager named Schneider."
Tony, Grammy, Emmy and Oscar winner Moreno has been cast as the grandmother. No other casting has been reported.
Writers Royce and Kellett will executive produce the series with Lear, Michael Garcia and Brent Miller.
A premiere date has yet to be announced.