Parsons sits down with host James Lipton for the 8 PM ET broadcast; check local listings.
Parsons is a four-time Emmy winner best known for his work on TV's "The Big Bang Theory."
"Having an incredibly well-rounded, successful run in theater, film and television, Jim Parsons arrived on our stage for one of the most joyful—and hilarious—evenings in the 21-year history of Inside the Actors Studio," host Lipton said in an earlier statement.
Parsons was previously seen on Broadway in Harvey and The Normal Heart.
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A repeat of an earlier "Inside the Actors Studio" with Tony winner Neil Patrick Harris airs at 7 PM ET.
