The musical guest for the evening is The 1975.
David, best known as the creator and star of "Curb Your Enthusiasm" and the co-creator of "Seinfeld," will likely repeat his Bernie Sanders impression, which he has performed twice this season on the long-running sketch comedy show.
David also spent time as a "Saturday Night Live" writer three decades ago.
"Saturday Night Live" is broadcast on NBC beginning at 11:29 PM ET; check local listings.